In 1983, a monoclonal antibody, Ki67, was generated, that labeled the nuclei of proliferating
non-neoplastic and neoplastic cells. The name Ki67 derived from the city of Kiel (Ki) where …

Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplastic proliferations
showing different morphological features, immunophenotype, molecular background …

The introduction of Ki67 immunohistochemistry in the work-up of neuroendocrine neoplasms
(NENs) has opened a new approach for their diagnosis and prognostic evaluation. Since the …

Gastro-entero-pancreatic neuroendocrine neoplasia (GEP-NENs) are rare tumors, but their
frequency is increasing. Neuroendocrine tumors normally express somatostatin (SST) …

Background Surgery for small intestinal neuroendocrine tumours (SI-NETs) is limited by
metastatic disease in most patients. However, resection of the primary lesion alone has …

Purpose Temozolomide (TEM) based therapy has been reported being effective in the
treatment of metastatic neuroendocrine neoplasms (NEN), with response rates ranging from …

Everolimus is a valid therapeutic option for neuroendocrine tumors (NETs); however, data in
a real-world setting outside regulatory trials are sparse. The aim of this study was to …

Abstract Background/Aims: Plasma chromogranin A (CgA) is the most widely used
biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic …

Background This study aimed to evaluate the outcome of patients with type 1 gastric
neuroendocrine neoplasia (T1gNENs) treated with different endoscopic approaches …

Introduction: In patients with small intestinal neuroendocrine tumors (siNETs), surgical
resection of the primary tumor and associated mesenteric lymph nodes (LNs) is …