[HTML][HTML] Hepatitis C virus: Morphogenesis, infection and therapy

VA Morozov, S Lagaye - World journal of hepatology, 2018 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) is a major cause of liver diseases including liver cirrhosis and
hepatocellular carcinoma. Approximately 3% of the world population is infected with HCV …

Genetic diversity and evolution of hepatitis C virus–15 years on

P Simmonds - Journal of General Virology, 2004 - microbiologyresearch.org
In the 15 years since the discovery of hepatitis C virus (HCV), much has been learned about
its role as a major causative agent of human liver disease and its ability to persist in the face …

[PDF][PDF] Structural biology of hepatitis C virus

F Penin, J Dubuisson, FA Rey, D Moradpour… - …, 2004 - Wiley Online Library
Hepatitis C virus (HCV) causes acute and chronic liver disease in humans, including chronic
hepatitis, cirrhosis, and hepatocellular carcinoma. Studies of this virus have been hampered …

Bats are a major natural reservoir for hepaciviruses and pegiviruses

PL Quan, C Firth, JM Conte… - Proceedings of the …, 2013 - National Acad Sciences
Although there are over 1,150 bat species worldwide, the diversity of viruses harbored by
bats has only recently come into focus as a result of expanded wildlife surveillance. Such …

Viral hepatitis and liver cancer: the case of hepatitis C

M Levrero - Oncogene, 2006 - nature.com
Chronic infection with the hepatitis C virus (HCV) is a major risk factor for the development of
hepatocellular carcinoma (HCC) worldwide. The pathogenesis of HCC in HCV infection has …

Evidence for novel hepaciviruses in rodents

JF Drexler, VM Corman, MA Müller… - PLoS …, 2013 - journals.plos.org
Hepatitis C virus (HCV) is among the most relevant causes of liver cirrhosis and
hepatocellular carcinoma. Research is complicated by a lack of accessible small animal …

Characterization of a canine homolog of hepatitis C virus

A Kapoor, P Simmonds, G Gerold… - Proceedings of the …, 2011 - National Acad Sciences
An estimated 3% of the world's population is chronically infected with hepatitis C virus
(HCV). Although HCV was discovered more than 20 y ago, its origin remains obscure largely …

The NS5A protein of hepatitis C virus is a zinc metalloprotein

TL Tellinghuisen, J Marcotrigiano… - Journal of Biological …, 2004 - ASBMB
The NS5A protein of hepatitis C virus is believed to be an integral part of the viral replicase.
Despite extensive investigation, the role of this protein remains elusive. Only limited …

Novel insights into hepatitis C virus replication and persistence

R Bartenschlager, M Frese… - Advances in virus …, 2004 - books.google.com
C. Proteolytic Processing of Structural Proteins D. Proteolytic Processing of Nonstructural
Proteins E. Cis-Acting RNA Sequences Required for Replication F. Mechanism of RNA …

Quantitative analysis of the hepatitis C virus replication complex

D Quinkert, R Bartenschlager, V Lohmann - Journal of virology, 2005 - Am Soc Microbiol
The hepatitis C virus (HCV) encodes a large polyprotein; therefore, all viral proteins are
produced in equimolar amounts regardless of their function. The aim of our study was to …