Although many kinds of therapies are applied in the clinic, drug-resistance is a major and
unavoidable problem. Another disturbing statistic is the limited number of drug targets, which …

The search is on for effective specific inhibitors for PI3Kα mutants. PI3Kα, a critical lipid
kinase, has two subunits, catalytic and inhibitory. PIK3CA, the gene that encodes the p110α …

Dysfunctional signaling through the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway
leads to uncontrolled tumor proliferation. In the course of the discovery of novel benzoxepin …

There are over 500 human kinases ranging from very well-studied to almost completely
ignored. Kinases are tractable and implicated in many diseases, making them ideal targets …

Abstract PI3K/Akt/mTOR pathway is crucial for carcinogenesis and its inhibitors have made a
great progress in cancer treatment. However, there is still a great developing space for PI3K …

Phosphatidylinositol 3-kinases (PI3Ks) are important therapeutic targets for the treatment of
cancer, thrombosis, and inflammatory and immune diseases. The four highly homologous …

Simple Summary Breast cancer remains the fourth-leading cause of death worldwide, and
therapeutic improvement is warranted. The phosphatidylinositol 3-kinase (PI3K) pathway is …

A new palladium-catalyzed annulative allylic alkylation (AAA) reaction of 2-(indol-2-yl)
phenols with dual allylic electrophiles such as isobutylene dicarbonate and butene …

It is generally understood that the antitumor properties of synthetic heterocyclic compounds
are among the most powerful properties that can be made use in medicinal chemistry. More …

Heterocyclic compounds play an important role in the field of pharmaceutical chemistry,
especially compounds containing hybrid bioactive moieties. So in continuation of our work …