The dietary recommendation encourages reducing saturated fatty acids (SFA) in diet and
replacing them with polyunsaturated fatty acids (PUFAs) n–3 (omega–3) and n–6 (omega …

The endocannabinoid system consists of G protein-coupled cannabinoid CB 1 and CB 2
receptors, of endogenous compounds known as endocannabinoids that can target these …

Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in
energy homeostasis. However, clinical trials with the first generation of CB1 blockers, now …

Clinical studies suggest that diets rich in ω-3 polyunsaturated fatty acids (PUFAs) provide
beneficial anti-inflammatory effects, in part through their conversion to bioactive metabolites …

Cannabinoids, the active components of cannabis (Cannabis sativa) extracts, have attracted
the attention of human civilizations for centuries, much earlier than the discovery and …

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors,
the primary molecular targets responsible for the pharmacological effects of the Δ9 …

Changes in lipid metabolism are intimately related to cancer. Several classes of bioactive
lipids play roles in the regulation of signaling pathways involved in neoplastic transformation …

Notwithstanding the ongoing debate on their full potential in health and disease, there is
general consensus that n-3 PUFAs play important physiological roles. Increasing dietary n-3 …

Background: Dietary essential omega-6 (n-6) and omega-3 (n-3) 18 carbon (18C-)
polyunsaturated fatty acids (PUFA), linoleic acid (LA) and α-linolenic acid (ALA), can be …

Among a variety of phytocannabinoids, Δ 9-tetrahydrocannabinol (THC) and cannabidiol
(CBD) are the most promising therapeutic compounds. Besides the well-known palliative …