Telomere shortening at chromosomal ends due to the constraints of the DNA replication
process acts as a tumor suppressor by restricting the replicative potential in primary cells …

Neurodevelopmental disorders (NDDs) arise from the disruption of highly coordinated
mechanisms underlying brain development, which results in impaired sensory, motor and/or …

Abstract Alternative Lengthening of Telomeres (ALT) is an aberrant DNA recombination
pathway which grants replicative immortality to approximately 10% of all cancers. Despite …

Overcoming replicative senescence is an essential step during oncogenesis, and the
reactivation of TERT through promoter mutations is a common mechanism. TERT promoter …

Mutations in the shelterin protein POT1 are associated with chronic lymphocytic leukemia
(CLL), Hodgkin lymphoma, angiosarcoma, melanoma, and other cancers. These cancer …

Mutations in the TINF2 gene, encoding the shelterin protein TIN2, cause telomere
shortening and the inherited bone marrow (BM) failure syndrome dyskeratosis congenita …

Laminins (LNs) play a central role in the self-assembly and maintenance of basement
membranes and are involved in critical interactions between cells and other extracellular …

Telomeres, the ends of eukaryotic chromosomes, protect genome integrity and enable cell
proliferation. Maintaining optimal telomere length in the germline and throughout life limits …

端粒位于真核生物染色体末端, 在复制过程中保护染色体的完整性. 端粒随着细胞的有丝分裂而
缩短, 端粒酶在胚胎干细胞等细胞中起到了延长端粒的作用. 端粒结合蛋白包括shelterin …

The work presented in this thesis was conducted by me and other members of the laboratory
and the study was supported by a research collaboration. I was involved in the …