Autoimmune diseases recognize a multifactorial pathogenesis, although the exact
mechanism responsible for their onset remains to be fully elucidated. Over the past few …

The liver is an important immunological site that can promote immune tolerance or
activation. Natural killer (NK) cells are a major immune subset within the liver, and therefore …

XPO1 (Exportin-1/CRM1) is a nuclear export protein that is frequently overexpressed in
cancer and functions as a driver of oncogenesis. Currently small molecules that target XPO1 …

Primary biliary cholangitis (PBC) is an autoimmune liver disease with striking female
predisposition, and selective destruction of intrahepatic small bile ducts leading to non …

BACKGROUND Liver fibrosis is a refractory disease whose persistence can eventually
induce cirrhosis or even liver cancer. Early liver fibrosis is reversible by intervention. As a …

Primary biliary cholangitis (PBC) is a rare autoimmune disease of the liver affecting the small
bile ducts. From a genetic point of view, PBC is a complex trait and several genetic and …

Invariant natural killer T cells (iNKT cells) constitute a specialized subset of lymphocytes that
bridges innate and adaptive immunity through a combination of traits characteristic of both …

Objective Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1, ILC2,
lymphoid tissue-inducer (LTi) cells, and ILC3 cell, play a key role in various immune …

Fibrates, which are agonists of peroxisome proliferator-activated receptor alpha, have
received increasing attention in the treatment of primary biliary cholangitis. Reduced …

Cholestasis is one of the most common clinical symptom of liver diseases. If patients do not
receive effective treatment, cholestasis can evolve into liver fibrosis, cirrhosis and ultimately …