T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Abstract IL-17-producing T helper (Th17) cells have been implicated in the pathogenesis of
many inflammatory and autoimmune diseases. Targeting the effector cytokines IL-17 and …

Granulocyte–macrophage colony-stimulating factor (GM-CSF) has many more functions
than its original in vitro identification as an inducer of granulocyte and macrophage …

There is growing recognition that B cell contributions to normal immune responses extend
well beyond their potential to become antibody-producing cells, including roles at the innate …

Most tissues are populated by tissue-resident memory T cells (TRM cells), which are
adapted to their niche and appear to be indispensable for local protection against …

Recurrent medulloblastoma and ependymoma are universally lethal, with no approved
targeted therapies and few candidates presently under clinical evaluation. Nearly all …

A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated
in the pathogenesis of chronic inflammatory and autoimmune diseases. A positive effect of …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial
cytokine produced by auto-reactive T helper (Th) cells that initiate tissue inflammation …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a
growth factor that induces the differentiation and proliferation of myeloid progenitors in the …

Cytokine dysregulation is a central driver of chronic inflammatory diseases such as multiple
sclerosis (MS). Here, we sought to determine the characteristic cellular and cytokine …