The identification of the multiple endocrine neoplasia type 1 (MEN1) gene in 1997 has
shown that germline heterozygous mutations in the MEN1 gene located on chromosome …

Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant inherited tumor
syndrome, associated with parathyroid, pituitary, and gastro-entero-pancreatic (GEP) …

Osteocytes are the terminally differentiated cell type of the osteoblastic lineage and have
important functions in skeletal homeostasis. Although the transcriptional regulation of …

Context The skeletal involvement of multiple endocrine neoplasia type 1-related primary
hyperparathyroidism (MHPT) is not exactly the same as that of sporadic primary …

Key points Multiple endocrine neoplasia type 1 is a rare genetic syndrome, characterized by
the co-occurrence, in the same individual or in related individuals of the same family, of …

During osteoporosis bone formation by osteoblasts is reduced and/or bone resorption by
osteoclasts is enhanced. Currently, only a few factors have been identified in the regulation …

Multiple endocrine neoplasia type 1 (MEN1) is inherited as an autosomal dominant disorder.
1, 2 It has a prevalence of 2 to 3 per 100,000 3 and is reported to be present in 0.22% to …

The identification of the multiple endocrine neoplasia type 1 (MEN1) gene in 1997 has
shown that germline heterozygous mutations in the MEN1 gene located on chromosome …

Osteoclasts can interact with osteosarcoma to promote the growth of osteosarcoma.
Cisplatin is common in adjuvant chemotherapy of osteosarcoma. However, due to …

The inactivation of p53 creates a major challenge for inducing apoptosis in cancer cells. An
attractive strategy is to identify and subsequently target the survival signals in p53 defective …