Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Senescent cells are highly associated with aging and pathological conditions and could be
targeted to slow the aging process. One commonly used marker to examine senescent cells …

Cellular senescence contributes to Alzheimer's disease (AD) pathogenesis. An open-label,
proof-of-concept, phase I clinical trial of orally delivered senolytic therapy, dasatinib (D) and …

The concept of senescence as a phenomenon limited to proliferating cells has been
challenged by growing evidence of senescence-like features in terminally differentiated …

Cellular senescence is a state of terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells …

Senescence is a programmed cellular response that can be activated after stress and
culminates in a distinctive change of cell state. When faced with irreparable damage …

Vascular endothelial cells play an important role in maintaining brain health, but their
contribution to Alzheimer's disease (AD) is obscured by limited understanding of the cellular …

Alzheimer's disease (AD) is a brain disorder that progressively undermines memory and
thinking skills by affecting the hippocampus and entorhinal cortex. The main …

Cellular senescence, a state of irreversible cell-cycle arrest caused by a variety of cellular
stresses, is critically involved in age-related tissue dysfunction in various organs. However …

Senescent cells accumulate throughout the body with advanced age, diseases and chronic
conditions. They negatively impact health and function of multiple systems, including the …