Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects,
ranging from antioxidant and anti-inflammatory effects to the production of active thyroid …

The epilepsies are a heterogeneous group of disorders characterized by the propensity to
experience spontaneous recurrent seizures. Epilepsies can be genetic or acquired, and the …

Multiple biological functions of selenium manifest themselves mainly via 25 selenoproteins
that have selenocysteine at their active centre. Selenium is vital for the brain and seems to …

An insult to the brain (such as the first seizure) causes excitotoxicity, neuroinflammation, and
production of reactive oxygen/nitrogen species (ROS/RNS). ROS and RNS produced during …

Selenoproteins are proteins containing selenium in the form of the 21st amino acid,
selenocysteine. Members of this protein family have many diverse functions, but their …

Selenoproteins are important for normal brain function, and decreased function of
selenoproteins can lead to impaired cognitive function and neurological disorders. This …

Epilepsy is one of the oldest neurological conditions known to humankind. It is known that
oxidative stress and generation of reactive oxygen species are a cause and consequence of …

Oxidative stress, a state of imbalance in the production of reactive oxygen species and
nitrogen, is induced by a wide variety of factors. This biochemical state is associated with …

The essential trace element, selenium (Se), is crucial to the brain but it may be potentially
neurotoxic, depending on dosage and speciation; Se has been discussed for decades in …

To understand the biochemistry of methylmercury (MeHg) that leads to the formation of
mercury-selenium (Hg-Se) clusters is a long outstanding challenge that promises to deepen …