Bulk sequencing methodologies have allowed us to make great progress in cancer
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …

Functional precision medicine is a new, emerging area that can guide cancer treatment by
capturing information from direct perturbations of tumor-derived, living cells, such as by drug …

Adoptive cell therapy (ACT) constitutes a major breakthrough in cancer management that
has expanded in the past years due to impressive results showing durable and even …

Despite recent progress in identifying the genetic drivers of acute lymphoblastic leukemia
(ALL), prognosis remains poor for those individuals who experience disease recurrence …

Abstract Advanced three-dimensional (3D) cell models have proven to be capable of
depicting architectural and microenvironmental features of several tissues. By providing data …

Clonal hematopoiesis (CH) defines a premalignant state predominantly found in older
persons that increases the risk of developing hematologic malignancies and age-related …

Aberrant metabolism contributes to tumor initiation, progression, metastasis, and drug
resistance. Metabolic dysregulation has emerged as a hallmark of several hematologic …

Our current understanding of human hematopoiesis has undergone significant
transformation throughout the years, challenging conventional views. The evolution of high …

Alterations in epigenetic marks, such as DNA methylation, represent a hallmark of cancer
that has been successfully exploited for therapy in myeloid malignancies. Hypomethylating …

Advances in DNA sequencing technology have significantly impacted human genetics; they
have enabled the analysis of genetic causes of rare diseases, which are usually pathogenic …