The lymphatic system (LS) is composed of lymphoid organs and a network of vessels that
transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in …

Secondary lymphoid organs, such as lymph nodes, harbor highly specialized and
compartmentalized niches. These niches are optimized to facilitate the encounter of naive …

Single-cell technologies have recently allowed the identification of multiple lymphatic
endothelial cell (LEC) subsets in subcapsular, paracortical, medullary, and other lymph …

Antigens from viruses or immunizations can persist or are archived in lymph node stromal
cells such as lymphatic endothelial cells (LEC) and fibroblastic reticular cells (FRC). Here …

Primary immune responses following vaccination are initiated in draining lymph nodes,
where naive T and B cells encounter Ag and undergo coordinated steps of activation. For …

In response to infection or vaccination, the immune system initially responds non-specifically
to the foreign insult (innate) and then develops a specific response to the foreign antigen …

The tumor microenvironment (TME) is an intricate complex and dynamic structure composed
of various cell types, including tumor, stromal and immune cells. Within this complex …

Viremia in the vertebrate host is a major determinant of arboviral reservoir competency,
transmission efficiency, and disease severity. However, immune mechanisms that control …

Infection with chikungunya virus (CHIKV) causes disruption of draining lymph node (dLN)
organization, including paracortical relocalization of B cells, loss of the B cell–T cell border …

Mycobacterium tuberculosis (Mtb) infection elicits both protein and lipid antigen-specific T
cell responses. However, the incorporation of lipid antigens into subunit vaccine strategies …