The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Centromeres are the chromosomal domains required to ensure faithful transmission of the
genome during cell division. They have a central role in preventing aneuploidy, by …

In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore,
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …

Neurons are terminally differentiated cells that use their microtubule arrays not for cell
division but rather as architectural elements required for the elaboration of elongated axons …

Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move
along the surface of, or destabilize, microtubule filaments. Much progress has been made in …

Kinetochores are macromolecular machines that couple chromosomes to dynamic
microtubule tips during cell division, thereby generating force to segregate the …

The microtubule cytoskeleton and the mitotic spindle are highly dynamic structures, yet their
sizes are remarkably constant, thus indicating that the growth and shrinkage of their …

Abstract The small nuclear GTPase Ran controls the directionality of macromolecular
transport between the nucleus and the cytoplasm. Ran also has important roles during …

The molecular mechanisms by which microtubule-associated proteins (MAPs) regulate the
dynamic properties of microtubules (MTs) are still poorly understood. We review recent …