Nuclear receptors have a broad spectrum of biological functions in normal physiology and in
the pathology of various diseases, including glomerular disease. The primary therapies for …

The resurgence of research in podocyte biology over the past decade underscores the
importance of this unique cell in preserving glomerular structure and function. A greater …

Extracts of Tripterygium wilfordii Hook F have been used to treat glomerulonephritis for more
than 30 years in China with dramatic antiproteinuric effects. Triptolide, a diterpene …

Context.—Etiologic factors and pathways leading to altered podocyte phenotype are clearly
numerous and involve the activity of different cellular function. Objective.—To focus on …

Tubular injury and interstitial fibrosis are the hallmarks of chronic kidney disease. While
recent studies have verified that proximal tubular injury triggers interstitial fibrosis, the impact …

ATRA induces podocyte differentiation and alters nephrin and podocin expression in vitro
and in vivo. Background Podocytes are terminally differentiated and highly specialized …

Retinoic acid treatment protects MRL/lpr lupus mice from the development of glomerular
disease. Background Retinoic acid (tRA) is an active metabolite of vitamin A with potent anti …

We previously reported that diabetes decreased the expression of renal tight junction (TJ)
proteins claudin-5 in glomerulus, and claudin-2 and occludin in proximal tubule through an …

The primary etiology of CKD is a direct consequence of initial dysfunction and injury of the
glomerulus, the main filtration system. Podocytes are terminally differentiated epithelial cells …

HIV-associated nephropathy is characterized by renal podocyte proliferation and
dedifferentiation. This study found that all-trans retinoic acid (atRA) reverses the effects of …