Engineering the multiscale complexity of vascular networks
The survival of vertebrate organisms depends on highly regulated delivery of oxygen and
nutrients through vascular networks that pervade nearly all tissues in the body …
nutrients through vascular networks that pervade nearly all tissues in the body …
Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment
Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …
modulating patients' own immune systems and unleashing pre-existing immunity. However …
Design and engineering of organ-on-a-chip
S Cho, S Lee, SI Ahn - Biomedical engineering letters, 2023 - Springer
Abstract Organ-on-a-chip (OOC) is an emerging interdisciplinary technology that
reconstitutes the structure, function, and physiology of human tissues as an alternative to …
reconstitutes the structure, function, and physiology of human tissues as an alternative to …
Angiogenesis-on-a-chip coupled with single-cell RNA sequencing reveals spatially differential activations of autophagy along angiogenic sprouts
Several functions of autophagy associated with proliferation, differentiation, and migration of
endothelial cells have been reported. Due to lack of models recapitulating angiogenic …
endothelial cells have been reported. Due to lack of models recapitulating angiogenic …
Engineering organ-on-a-chip to accelerate translational research
We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-
chip technology is a form of microengineered cell culture platform that elaborates the in-vivo …
chip technology is a form of microengineered cell culture platform that elaborates the in-vivo …
In situ biosensing technologies for an organ-on-a-chip
The in vitro simulation of organs resolves the accuracy, ethical, and cost challenges
accompanying in vivo experiments. Organoids and organs-on-chips have been developed …
accompanying in vivo experiments. Organoids and organs-on-chips have been developed …
High-Throughput 3D In Vitro Tumor Vasculature Model for Real-Time Monitoring of Immune Cell Infiltration and Cytotoxicity
Recent advances in anticancer therapy have shown dramatic improvements in clinical
outcomes, and adoptive cell therapy has emerged as a type of immunotherapy that can …
outcomes, and adoptive cell therapy has emerged as a type of immunotherapy that can …
Fabrication of a self-assembled and vascularized tumor array via bioprinting on a microfluidic chip
G Lee, SJ Kim, JK Park - Lab on a Chip, 2023 - pubs.rsc.org
A tumor microenvironment (TME) is a complex system that comprises various components,
including blood vessels that play a crucial role in supplying nutrients, oxygen, and growth …
including blood vessels that play a crucial role in supplying nutrients, oxygen, and growth …
Microfluidic‐Based Reconstitution of Functional Lymphatic Microvasculature: Elucidating the Role of Lymphatics in Health and Disease
The knowledge of the blood microvasculature and its functional role in health and disease
has grown significantly attributable to decades of research and numerous advances in cell …
has grown significantly attributable to decades of research and numerous advances in cell …