Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …

The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

Centromeric integrity is key for proper chromosome segregation during cell division.
Centromeres have unique chromatin features that are essential for centromere …

The short arms of the human acrocentric chromosomes 13, 14, 15, 21 and 22 (SAACs) share
large homologous regions, including ribosomal DNA repeats and extended segmental …

Chromatin is organized into higher-order structures that form subcompartments in
interphase nuclei. Different categories of specialized enzymes act on chromatin and …

Heterochromatin mainly comprises repeated DNA sequences that are prone to ectopic
recombination. In Drosophila cells,'safe'repair of heterochromatic double-strand breaks by …

Programmable nucleases have enabled rapid and accessible genome engineering in
eukaryotic cells and living organisms. However, their delivery into target cells can be …

To ward off against the catastrophic consequences of persistent DNA double-strand breaks
(DSBs), eukaryotic cells have developed a set of complex signaling networks that detect …

DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or
chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede DNA-based …

The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that
are responsible for protein synthesis. A wealth of research over the past 20 years has clearly …