Biotechnological approaches for producing natural pigments in yeasts

A Bernard, T Rossignol, YK Park - Trends in Biotechnology, 2024 - cell.com
Pigments are widely used in the food, cosmetic, textile, pharmaceutical, and materials
industries. Demand for natural pigments has been increasing due to concerns regarding …

75 years of vitamin A production: a historical and scientific overview of the development of new methodologies in chemistry, formulation, and biotechnology

W Bonrath, B Gao, P Houston… - … Process Research & …, 2023 - ACS Publications
In 1948, the first kilograms of synthetic vitamin A (acetate) were produced by F. Hoffmann-La
Roche, eliminating the need to extract this vital compound from natural sources; this year …

From β-Carotene to Retinoids: A Review of Microbial Production of Vitamin A

Y Zhang, H Yu, L Ye - Journal of Agricultural and Food Chemistry, 2024 - ACS Publications
Vitamin A (retinoids) is crucial for human health, with significant demand across the food,
pharmaceutical, and animal feed industries. Currently, the market primarily relies on …

Efficient production of retinol in Yarrowia lipolytica by increasing stability using antioxidant and detergent extraction

H Park, D Lee, JE Kim, S Park, JH Park, CW Ha… - Metabolic …, 2022 - Elsevier
The demand for bio-based retinol (vitamin A) is currently increasing, however its instability
represents a major bottleneck in microbial production. Here, we developed an efficient …

RDH12 retinopathy: clinical features, biology, genetics and future directions

M Daich Varela, M Michaelides - Ophthalmic Genetics, 2022 - Taylor & Francis
ABSTRACT Retinol dehydrogenase 12 (RDH12) is a small gene located on chromosome
14, encoding an enzyme capable of metabolizing retinoids. It is primarily located in …

Multi-level engineering of Saccharomyces cerevisiae for the synthesis and accumulation of retinal

Q Mo, W Song, Z Xue, J Yuan - Green Chemistry, 2022 - pubs.rsc.org
Owing to the pharmaceutical value of retinal (vitamin A aldehyde), there is an increasing
demand for the microbial synthesis of bio-based retinal. However, its microbial production is …

Cas9-Based Metabolic Engineering of Issatchenkia orientalis for Enhanced Utilization of Cellulosic Hydrolysates

YG Lee, C Kim, N Kuanyshev, NK Kang… - Journal of Agricultural …, 2022 - ACS Publications
Issatchenkia orientalis, exhibiting high tolerance against harsh environmental conditions, is
a promising metabolic engineering host for producing fuels and chemicals from cellulosic …

Metabolic Engineering of Saccharomyces cerevisiae for Efficient Retinol Synthesis

X Wang, X Xu, J Liu, Y Liu, J Li, G Du, X Lv, L Liu - Journal of Fungi, 2023 - mdpi.com
Retinol, the main active form of vitamin A, plays a role in maintaining vision, immune
function, growth, and development. It also inhibits tumor growth and alleviates anemia. Here …

Metabolic Pathway Coupled with Fermentation Process Optimization for High-Level Production of Retinol in Yarrowia lipolytica

X Ren, M Liu, M Yue, W Zeng, S Zhou… - Journal of Agricultural …, 2024 - ACS Publications
Retinol is a lipid-soluble form of vitamin A that is crucial for human visual and immune
functions. The production of retinol through microbial fermentation has been the focus of …

Enhanced production of 3, 4‐dihydroxybutyrate from xylose by engineered yeast via xylonate re‐assimilation under alkaline condition

T Yukawa, T Bamba, M Matsuda… - Biotechnology and …, 2023 - Wiley Online Library
To realize lignocellulose‐based bioeconomy, efficient conversion of xylose into valuable
chemicals by microbes is necessary. Xylose oxidative pathways that oxidize xylose into …