Anhedonia is considered a core feature of major depressive disorder, and the dopamine
system plays a pivotal role in the hedonic deficits described in this disorder. Dopaminergic …

Despite being considered primarily a mood disorder, major depressive disorder (MDD) is
characterized by cognitive and decision making deficits. Recent research has employed …

One of the most important developments in psychosocial approaches to emotional problems
has been the success of cognitive therapy for depression. Evidence for the powerful efficacy …

Abstract Treatment resistance to the antidepressive pharmacotherapy represents one of the
most important clinical challenges in the pharmacological management of unipolar …

Depression is a severe mental health problem that affects people regardless of social status
or education, is associated with changes in mood and behavior, and can result in a suicide …

In addition to electroconvulsive therapy (ECT) and repetitive transcranial magnetic
stimulation (rTMS), vagus nerve stimulation (VNS) is one of the approved neurostimulation …

Major depression is a prevalent and debilitating disorder and a substantial proportion of
patients fail to reach remission following standard antidepressant pharmacological …

Major depressive disorder (MDD) is associated with a significant burden and costs to the
society. As remission of depressive symptoms is achieved in only one-third of the MDD …

We conducted a systematic review and meta-analysis on whether memantine was beneficial
for the treatment of depressive symptoms in major depressive disorder (MDD) and bipolar …

Background Initial improvement in the first weeks of antidepressant (AD) treatment is a
useful early predictor of complete AD response. We performed a meta-analysis of AD …