T cell immunoglobulin and mucin domain 3 (TIM-3) expression on malignant cells has been
reported in some leukemias. In myelodysplastic syndrome (MDS), increased TIM-3 …

Escape from immune surveillance is a hallmark of cancer. Immune deregulation caused by
intrinsic and extrinsic cellular factors, such as altered T-cell functions, leads to immune …

CD8+ T cells play a central role in antitumour immunity, which often exhibit 'exhaustion'in the
setting of malignancy and chronic viral infection due to T cell immunoglobulin and mucin …

Persistent exposure to tumor antigens results in exhausted tumor-infiltrating T cells (TILs)
that express the immune checkpoint molecules, PD-1 and Tim3, and lack anti-tumor …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that play a critical immunosuppressive role in the tumour micro-environment …

T cell immunoglobulin and mucin domain-3 (TIM-3), a crucial immune checkpoint following
PD1 and CTLA4, is widely found in several immune cells. Nonetheless, its performance in …

Myelodysplastic syndromes (MDS) constitute a very heterogeneous group of diseases with a
high prevalence in elderly patients and a propensity for progression to acute myeloid …

The pathophysiology of myelodysplastic syndromes (MDSs) is complex and often includes
immune dysregulation of both the innate and adaptive immune systems. Whereas clonal …

Introduction Myelodysplastic syndromes (MDS) are heterogeneous group of clonal
hematopoietic stem cell neoplasms that have limited approved treatment options. Multiple …

Simple Summary Immunotherapeutic synergy represents the cornerstone of the treatment
intended for patients with clear-cell renal-cell carcinoma. In most cases, this type of cancer …