Significance: Angiogenesis, the growth of new blood vessels from existing vessels, is an
important aspect of the repair process. Restoration of blood flow to damaged tissues …

Growth factors are important morphogenetic proteins that instruct cell behavior and guide
tissue repair and renewal. Although their therapeutic potential holds great promise in …

Venous leg ulcers account for approximately 70% of all leg ulcers and affect 2.2 million
Americans annually. After a comprehensive patient and wound assessment, compression …

Modern synthetic biomaterials are being designed to integrate bioactive ligands within
hydrogel scaffolds for cells to respond and assimilate within the matrix. These advanced …

Growth factors are very promising molecules to enhance bone regeneration. However, their
translation to clinical use has been seriously limited, facing issues related to safety and cost …

Significance: Growth factors are very promising molecules for the treatment of skin wounds.
However, their translation to clinical use has been seriously limited, facing issues related to …

Fibrin, a natural hydrogel, is the end product of the physiological blood coagulation cascade
and naturally involved in wound healing. Beyond its role in hemostasis, it acts as a local …

According to the World Health Organization (WHO), around 11 million people suffer from
burns every year, and 180,000 die from them. A burn is a condition in which heat, chemical …

All vertebrates possess mechanisms to restore damaged tissues with outcomes ranging
from regeneration to scarring. Unfortunately, the mammalian response to tissue injury most …

Tissue repair models are essential to explore the pathogenesis of wound healing and scar
formation, identify new drug targets/biomarkers and to test new therapeutics. However, no …