Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Dry Eye Dry eye is a common, painful ocular disturbance that can result from systemic
inflammatory diseases, localized eye problems, or commonly used medications. Current …

Extracellular DNA (exDNA) is abundant in many habitats, including soil, sediments, oceans
and freshwater as well as the intercellular milieu of metazoa. For a long time, its origin has …

Chronic graft-versus-host disease (GVHD) can be associated with significant morbidity, in
part because of nonreversible fibrosis, which impacts physical functioning (eye, skin, lung …

Ocular graft-versus-host disease (GVHD) occurs in more than half of patients who develop
chronic GVHD after allogeneic hematopoietic cell transplantation (HCT), causing prolonged …

Purpose: The meibomian glands are located in the tarsal plate of the upper and lower eyelid
and are responsible for the production of a lipid-rich secretion, the meibum, which forms the …

Analyzes of cell-free nucleic acids (cfNAs) have shown huge potential in many biomedical
applications, gradually entering several fields of research and everyday clinical care. Many …

Age-related eye diseases, including dry eye, glaucoma, age-related macular degeneration,
and diabetic retinopathy, represent a major global health issue based on their increasing …

Ocular graft-versus-host disease (GVHD) is a major complication after allogeneic
hematopoietic stem cell transplantation. Ocular GVHD affects recipients' visual function and …

Purpose.: To determine if hyperosmolar stress can stimulate human neutrophils to form
neutrophil extracellular traps (NETs) and to investigate potential strategies to reduce …