Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

Exercise has long been known for its active role in improving physical fitness and sustaining
health. Regular moderate-intensity exercise improves all aspects of human health and is …

Remodelling of the immune system with age—immunosenescence—is a substantial
contributor to poor health in older adults, with increasing risk of infections, cancer and …

Alzheimer's disease (AD) is a chronic neurodegenerative disease, with the characteristics of
neurofibrillary tangle (NFT) and senile plaque (SP) formation. Although great progresses …

Exercise stimulates the release of proteins with autocrine, paracrine, or endocrine functions
produced in skeletal muscle, termed myokines. Based on the current state of knowledge, the …

Physical inactivity or a sedentary lifestyle is a significant health concern worldwide. The
Centers for Disease Control (CDC) recommends 150 minutes per week of moderate to …

Immunosenescence is characterized by deterioration of the immune system caused by
aging which induces changes to innate and adaptive immunity. Immunosenescence affects …

Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in
part because exercise exerts anti-inflammatory effects. However, these effects are also likely …

With increasing age, the immune system undergoes a remodeling process, termed
immunosenescence, which is accompanied by considerable shifts in leukocyte …

The epidemic of obesity is a major challenge for health policymakers due to its far-reaching
effects on population health and potentially overwhelming financial burden on healthcare …