Glioblastoma (GBM) tumor microenvironment (TME) is a highly heterogeneous and complex
system, which in addition to cancer cells, consists of various resident brain and immune cells …

Cancer cells can organize and communicate in functional networks. Similarly to other
networks in biology and sociology, these can be highly relevant for growth and resilience. In …

A network of communicating tumour cells that is connected by tumour microtubes mediates
the progression of incurable gliomas. Moreover, neuronal activity can foster malignant …

Abstract Each year, about 5–6 cases out of 100,000 people are diagnosed with primary
malignant brain tumors, of which about 80% are malignant gliomas (MGs). Glioblastoma …

Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …

The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

Pediatric low-grade gliomas (pLGG) show heterogeneous responses to MAPK inhibitors
(MAPKi) in clinical trials. Thus, more complex stratification biomarkers are needed to identify …

System xc‐is an amino acid antiporter that typically mediates the exchange of extracellular l‐
cystine and intracellular l‐glutamate across the cellular plasma membrane. Studied in a …

Virus-induced cell death has long been thought of as a double-edged sword in the inhibition
or exacerbation of viral infections. The vital role of iron, an essential element for various …

Glioma is the most common malignant primary brain tumor. Its rapid growth is aided by
tumor-mediated glutamate release, creating peritumoral excitotoxic cell death and vacating …