[HTML][HTML] Intestinal barrier dysfunction as a key driver of severe COVID-19

EP Tsounis, C Triantos, C Konstantakis… - World Journal of …, 2023 - ncbi.nlm.nih.gov
The intestinal lumen harbors a diverse consortium of microorganisms that participate in
reciprocal crosstalk with intestinal immune cells and with epithelial and endothelial cells …

Long COVID as a tauopathy: of “Brain Fog” and “Fusogen Storms”

A Sfera, L Rahman… - International Journal of …, 2023 - mdpi.com
Long COVID, also called post-acute sequelae of SARS-CoV-2, is characterized by a
multitude of lingering symptoms, including impaired cognition, that can last for many months …

Cannabinoids alleviate the LPS-induced cytokine storm via attenuating NLRP3 inflammasome signaling and TYK2-mediated STAT3 signaling pathways in vitro

SV Suryavanshi, M Zaiachuk, N Pryimak, I Kovalchuk… - Cells, 2022 - mdpi.com
Cannabinoids, mainly cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), are the most
studied group of compounds obtained from Cannabis sativa because of their several …

Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic

A Hasankhani, A Bahrami, N Sheybani, B Aria… - Frontiers in …, 2021 - frontiersin.org
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …

Microvascular thrombosis as a critical factor in severe COVID-19

PP Wadowski, B Panzer, A Józkowicz… - International Journal of …, 2023 - mdpi.com
Platelet–endothelial interactions have a critical role in microcirculatory function, which
maintains tissue homeostasis. The subtle equilibrium between platelets and the vessel wall …

Gut-brain pathogenesis of post-acute COVID-19 neurocognitive symptoms

AM Plummer, YL Matos, HC Lin, SG Ryman… - Frontiers in …, 2023 - frontiersin.org
Approximately one third of non-hospitalized coronavirus disease of 2019 (COVID-19)
patients report chronic symptoms after recovering from the acute stage of severe acute …

SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade

F Samsudin, P Raghuvamsi, G Petruk… - Journal of molecular …, 2022 - academic.oup.com
Accumulating evidence indicates a potential role for bacterial lipopolysaccharide (LPS) in
the overactivation of the immune response during SARS-CoV-2 infection. LPS is recognized …

Viral load is associated with mitochondrial dysfunction and altered monocyte phenotype in acute severe SARS-CoV-2 infection

PRT Romão, PC Teixeira, L Schipper, I da Silva… - International …, 2022 - Elsevier
Monocytes play a major role in the initial innate immune response to SARS-CoV-2. Although
viral load may correlate with several clinical outcomes in COVID-19, much less is known …

Innate immune dysregulation in multisystem inflammatory syndrome in children (MIS-C)

J Isaza-Correa, L Ryan, L Kelly, J Allen, A Melo… - Scientific Reports, 2023 - nature.com
MIS-C is a systemic inflammation disorder with poorly characterised immunopathological
mechanisms. We compared changes in the systemic immune response in children with MIS …

Superantigens and SARS-CoV-2

A Hamdy, A Leonardi - Pathogens, 2022 - mdpi.com
It has been posited SARS-CoV-2 contains at least one unique superantigen-like motif not
found in any other SARS or endemic coronaviruses. Superantigens are potent antigens that …