Hemocompatibility challenge of membrane oxygenator for artificial lung technology

BPN Thi, BTD Nguyen, IS Jeong, JF Kim - Acta Biomaterialia, 2022 - Elsevier
The artificial lung (AL) technology is one of the membrane-based artificial organs that partly
augments lung functions, ie blood oxygenation and CO 2 removal. It is generally employed …

The roles of membrane technology in artificial organs: current challenges and perspectives

BT Duy Nguyen, HY Nguyen Thi, BP Nguyen Thi… - Membranes, 2021 - mdpi.com
The recent outbreak of the COVID-19 pandemic in 2020 reasserted the necessity of artificial
lung membrane technology to treat patients with acute lung failure. In addition, the aging …

Transplantation, bridging, and support technologies in pulmonary hypertension

L Savale, A Benazzo, P Corris… - European …, 2024 - publications.ersnet.org
Despite the progress made in medical therapies for treating pulmonary hypertension (PH), a
subset of patients remain susceptible to developing a maladaptive right ventricular …

In vitro models for thrombogenicity testing of blood-recirculating medical devices

DN Sarode, S Roy - Expert review of medical devices, 2019 - Taylor & Francis
Introduction: Blood-recirculating medical devices, such as mechanical circulatory support
(MCS), extracorporeal membrane oxygenators (ECMO), and hemodialyzers, are commonly …

In vivo 5 day animal studies of a compact, wearable pumping artificial lung

SP Madhani, BJ Frankowski, SH Ye, GW Burgreen… - ASAIO …, 2019 - journals.lww.com
Recent studies show improved outcomes in ambulated lung failure patients. Ambulation still
remains a challenge in these patients. This necessitates development of more compact and …

[HTML][HTML] A Wearable Extracorporeal CO2 Removal System with a Closed-Loop Feedback

A Zhang, BJ Haimowitz, K Tharwani, A Rojas-Peña… - Bioengineering, 2024 - mdpi.com
Extracorporeal Carbon Dioxide Removal (ECCO2R) systems support patients with severe
respiratory failure. Concurrent ambulation and physical therapy improve patient outcomes …

Shape design of an artificial pump-lung using high-resolution hemodynamic simulation with high-performance computing

W Chen, H Zheng, Z Yan, R Chen - Physics of Fluids, 2023 - pubs.aip.org
Accurate and fast prediction of the hemodynamics of the artificial pump-lung is critical in the
design process. In this study, a comprehensive computational framework, including a sliding …

Advances in extracorporeal membrane oxygenator design for artificial placenta technology

DG Blauvelt, EN Abada, P Oishi, S Roy - Artificial organs, 2021 - Wiley Online Library
Extreme prematurity, defined as a gestational age of fewer than 28 weeks, is a significant
health problem worldwide. It carries a high burden of mortality and morbidity, in large part …

Ambulatory 7-day mechanical circulatory support in sheep model of pulmonary hypertension and right heart failure

R Ukita, YJ Patel, WK Wu, SA Francois… - The Journal of Heart and …, 2024 - Elsevier
Background Right heart failure is the major cause of death in pulmonary hypertension. Lung
transplantation is the only long-term treatment option for patients who fail medical therapy …

Bench Validation of a Compact Low-Flow CO2 Removal Device

AG May, RG Jeffries, BJ Frankowski… - Intensive care medicine …, 2018 - Springer
Background There is increasing evidence demonstrating the value of partial extracorporeal
CO 2 removal (ECCO 2 R) for the treatment of hypercapnia in patients with acute …