Therapeutic targeting of regulatory T cells in cancer
F Shan, A Somasundaram, TC Bruno, CJ Workman… - Trends in cancer, 2022 - cell.com
The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …
Immune parameters affecting the efficacy of chemotherapeutic regimens
The outcome of chemotherapy can be influenced by the host immune system at multiple
levels. Chemotherapy can kill cancer cells by causing them to elicit an immune response or …
levels. Chemotherapy can kill cancer cells by causing them to elicit an immune response or …
Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer
Purpose Preclinical data suggest a contribution of the immune system to chemotherapy
response. In this study, we investigated the prespecified hypothesis that the presence of a …
response. In this study, we investigated the prespecified hypothesis that the presence of a …
Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical …
M Gobert, I Treilleux, N Bendriss-Vermare, T Bachelot… - Cancer research, 2009 - AACR
Immunohistochemical analysis of FOXP3 in primary breast tumors showed that a high
number of tumor-infiltrating regulatory T cells (Ti-Treg) within lymphoid infiltrates …
number of tumor-infiltrating regulatory T cells (Ti-Treg) within lymphoid infiltrates …
[HTML][HTML] Metabolic crosstalk in the breast cancer microenvironment
During tumorigenesis, breast tumour cells undergo metabolic reprogramming, which
generally includes enhanced glycolysis, tricarboxylic acid cycle activity, glutaminolysis and …
generally includes enhanced glycolysis, tricarboxylic acid cycle activity, glutaminolysis and …
[HTML][HTML] CD4+ and CD8+ T cells have opposing roles in breast cancer progression and outcome
Y Huang, C Ma, Q Zhang, J Ye, F Wang, Y Zhang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract The Cancer Immunoediting concept has provided critical insights suggesting dual
functions of immune system during the cancer initiation and development. However, the …
functions of immune system during the cancer initiation and development. However, the …
What are regulatory T cells (Treg) regulating in cancer and why?
TL Whiteside - Seminars in cancer biology, 2012 - Elsevier
The role regulatory T cells (Treg) play in cancer development and progression is not clear.
Earlier evidence suggested that CD4+ FOXP3+ CD25high Treg accumulate in tumors and …
Earlier evidence suggested that CD4+ FOXP3+ CD25high Treg accumulate in tumors and …
Pathologic Complete Response to Neoadjuvant Chemotherapy of Breast Carcinoma Is Associated with the Disappearance of Tumor-Infiltrating Foxp3+ Regulatory T …
Purpose: T-cell infiltration is associated with good tumor prognosis in many cancers. To
assess the capacity of neoadjuvant chemotherapy to affect T-cell infiltration in breast cancer …
assess the capacity of neoadjuvant chemotherapy to affect T-cell infiltration in breast cancer …
Tumor-infiltrating γδ T lymphocytes predict clinical outcome in human breast cancer
C Ma, Q Zhang, J Ye, F Wang, Y Zhang… - The Journal of …, 2012 - journals.aai.org
Understanding and dissecting the role of different subsets of regulatory tumor-infiltrating
lymphocytes (TILs) in the immunopathogenesis of individual cancer is a challenge for anti …
lymphocytes (TILs) in the immunopathogenesis of individual cancer is a challenge for anti …
In situ immune response after neoadjuvant chemotherapy for breast cancer predicts survival
Accumulating preclinical evidence suggests that anticancer immune responses contribute to
the success of chemotherapy. However, the predictive value of tumour‐infiltrating …
the success of chemotherapy. However, the predictive value of tumour‐infiltrating …