Dynamic interactions between gut microbiota and a host's innate and adaptive immune
systems are essential in maintaining intestinal homeostasis and inhibiting inflammation. Gut …

The microbial ecosystem that inhabits the gastrointestinal tract of all mammals—the gut
microbiota—has been in a symbiotic relationship with its hosts over many millennia. Thanks …

Background Baicalin, which is isolated from Radix Scutellariae, possesses strong biological
activities including an anti-inflammation property. Recent studies have shown that the anti …

A wide array of cell signaling mediators and their interactions play vital roles in
neuroinflammation associated with ischemia, brain trauma, developmental disorders and …

Recent evidence provides support for involvement of the microbiota-gut-brain axis in
Parkinson's disease (PD) pathogenesis. We propose that a pro-inflammatory intestinal …

The CNS is endowed with an elaborated response repertoire termed'neuroinflammation',
which enables it to cope with pathogens, toxins, traumata and degeneration. On the basis of …

Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …

Introduction In recent years, it has been described that the dysbiosis of the intestinal
microbiota plays a transcendental role in several pathologies. In this sense, the importance …

Objectives The first drug repurposed for the treatment of depression was the tuberculostatic
iproniazid. At present, drugs belonging to new classes of antidepressants still have …

The prevalence of anxiety, mood and trauma-and stress-related disorders are on the rise;
however, efforts to develop new and effective treatment strategies have had limited success …