Two decades of a protooncogene HPIP/PBXIP1: uncovering the tale from germ cell to cancer
SS Khumukcham, B Manavathi - … et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
Hematopoietic PBX interacting protein (HPIP or pre-B-cell leukemia transcription factor
interacting protein (PBXIP1) was discovered two decades ago as a corepressor of pre-B-cell …
interacting protein (PBXIP1) was discovered two decades ago as a corepressor of pre-B-cell …
A novel common variant in DCST2 is associated with length in early life and height in adulthood
RJP van der Valk, E Kreiner-Møller… - Human molecular …, 2015 - academic.oup.com
Common genetic variants have been identified for adult height, but not much is known about
the genetics of skeletal growth in early life. To identify common genetic variants that …
the genetics of skeletal growth in early life. To identify common genetic variants that …
[PDF][PDF] The LDB1 complex co-opts CTCF for erythroid lineage-specific long-range enhancer interactions
Lineage-specific transcription factors are critical for long-range enhancer interactions, but
direct or indirect contributions of architectural proteins such as CCCTC-binding factor …
direct or indirect contributions of architectural proteins such as CCCTC-binding factor …
HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion
Y Feng, X Xu, Y Zhang, J Ding, Y Wang, X Zhang… - Scientific reports, 2015 - nature.com
Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (HPIP) was
shown to play a role in cancer development and progression. However, the role of HPIP in …
shown to play a role in cancer development and progression. However, the role of HPIP in …
Unveiling the complexity of transcription factor networks in hematopoietic stem cells: implications for cell therapy and hematological malignancies
A Benyoucef, JJ Haigh, M Brand - Frontiers in Oncology, 2023 - frontiersin.org
The functionality and longevity of hematopoietic tissue is ensured by a tightly controlled
balance between self-renewal, quiescence, and differentiation of hematopoietic stem cells …
balance between self-renewal, quiescence, and differentiation of hematopoietic stem cells …
Identification of transcription factor co-regulators that drive prostate cancer progression
In prostate cancer (PCa), and many other hormone-dependent cancers, there is clear
evidence for distorted transcriptional control as disease driver mechanisms. Defining which …
evidence for distorted transcriptional control as disease driver mechanisms. Defining which …
Hematopoietic PBX-interacting protein (HPIP) is over expressed in breast infiltrative ductal carcinoma and regulates cell adhesion and migration through modulation …
The scaffolding protein, hematopoietic PBX-interacting protein (HPIP/PBXIP1), regulates cell
migration necessary for cancer cell dissemination. However, the mechanism that governs …
migration necessary for cancer cell dissemination. However, the mechanism that governs …
HPIP protooncogene differentially regulates metabolic adaptation and cell fate in breast cancer cells under glucose stress via AMPK and RNF2 dependent pathways
While cancer cells rewire metabolic pathways to sustain growth and survival under
metabolic stress in solid tumors, the molecular mechanisms underlying these processes …
metabolic stress in solid tumors, the molecular mechanisms underlying these processes …
Pre-B-cell leukemia homeobox interacting protein 1 is overexpressed in astrocytoma and promotes tumor cell growth and migration
DG van Vuurden, E Aronica, E Hulleman… - Neuro …, 2014 - academic.oup.com
Background Glial brain tumors cause considerable mortality and morbidity in children and
adults. Innovative targets for therapy are needed to improve survival and reduce long-term …
adults. Innovative targets for therapy are needed to improve survival and reduce long-term …
O-GlcNAc homeostasis contributes to cell fate decisions during hematopoiesis
The addition of a single β-d-GlcNAc sugar (O-GlcNAc) by O-GlcNAc-transferase (OGT) and
O-GlcNAc removal by O-GlcNAcase (OGA) maintain homeostatic O-GlcNAc levels on …
O-GlcNAc removal by O-GlcNAcase (OGA) maintain homeostatic O-GlcNAc levels on …