[HTML][HTML] Brain manganese and the balance between essential roles and neurotoxicity

RC Balachandran, S Mukhopadhyay, D McBride… - Journal of Biological …, 2020 - ASBMB
Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …

[HTML][HTML] Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies

TV Peres, MRC Schettinger, P Chen… - BMC Pharmacology and …, 2016 - Springer
Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …

Water pollution indexing and health risk assessment due to PTE ingestion and dermal absorption for nine human populations in Southeast Nigeria

JC Agbasi, CN Chukwu, ND Nweke… - Groundwater for …, 2023 - Elsevier
Traditional human health risk assessment (HHRA) methods are now being replaced with
advanced codes. In the present study, HERisk code and water pollution index (WPI) were …

[PDF][PDF] Manganese in drinking-water: background document for development of WHO guidelines for drinking-water quality

World Health Organization - 2004 - apps.who.int
One of the primary goals of WHO and its member states is that “all people, whatever their
stage of development and their social and economic conditions, have the right to have …

Exposure to manganese in drinking water during childhood and association with attention-deficit hyperactivity disorder: a nationwide cohort study

J Schullehner, M Thygesen… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Manganese (Mn) in drinking water may increase the risk of several
neurodevelopmental outcomes, including attention-deficit hyperactivity disorder (ADHD) …

Manganese exposure and neurotoxic effects in children

G Bjørklund, MS Chartrand, J Aaseth - Environmental research, 2017 - Elsevier
Manganese (Mn) is the fifth most abundant metal on earth. Although it is a well understood
essential trace element, in excess, Mn is neurotoxic. Initial toxic symptoms associated with …

The effects of manganese overexposure on brain health

MR Miah, OM Ijomone, COA Okoh, OK Ijomone… - Neurochemistry …, 2020 - Elsevier
Manganese (Mn) is the twelfth most abundant element on the earth and an essential metal
to human health. Mn is present at low concentrations in a variety of dietary sources, which …

[HTML][HTML] Consequences of disturbing manganese homeostasis

J Baj, W Flieger, A Barbachowska, B Kowalska… - International Journal of …, 2023 - mdpi.com
Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …

Widespread copper and lead contamination of household drinking water, New South Wales, Australia

PJ Harvey, HK Handley, MP Taylor - Environmental research, 2016 - Elsevier
This study examines arsenic, copper, lead and manganese drinking water contamination at
the domestic consumer's kitchen tap in homes of New South Wales, Australia. Analysis of …

Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes

Z Zhang, J Yan, AB Bowman, MR Bryan, R Singh… - Autophagy, 2020 - Taylor & Francis
Epidemiological and clinical studies have long shown that exposure to high levels of heavy
metals are associated with increased risks of neurodegenerative diseases. It is widely …