Whole genome sequencing in clinical and public health microbiology

JC Kwong, N McCallum, V Sintchenko, BP Howden - Pathology, 2015 - Elsevier
Genomics and whole genome sequencing (WGS) have the capacity to greatly enhance
knowledge and understanding of infectious diseases and clinical microbiology. The growth …

Life after USA300: the rise and fall of a superbug

PJ Planet - The Journal of infectious diseases, 2017 - academic.oup.com
The community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)
epidemic in the United States is largely attributable to the meteoric rise of a single clone …

Application of whole-genome sequencing for bacterial strain typing in molecular epidemiology

SJ Salipante, DJ SenGupta, LA Cummings… - Journal of clinical …, 2015 - Am Soc Microbiol
Nosocomial infections pose a significant threat to patient health; however, the gold standard
laboratory method for determining bacterial relatedness (pulsed-field gel electrophoresis …

A year of infection in the intensive care unit: prospective whole genome sequencing of bacterial clinical isolates reveals cryptic transmissions and novel microbiota

DJ Roach, JN Burton, C Lee, B Stackhouse… - PLoS …, 2015 - journals.plos.org
Bacterial whole genome sequencing holds promise as a disruptive technology in clinical
microbiology, but it has not yet been applied systematically or comprehensively within a …

Longitudinal genomic surveillance of MRSA in the UK reveals transmission patterns in hospitals and the community

F Coll, EM Harrison, MS Toleman, S Reuter… - Science translational …, 2017 - science.org
Genome sequencing has provided snapshots of the transmission of methicillin-resistant
Staphylococcus aureus (MRSA) during suspected outbreaks in isolated hospital wards …

Clinical detection and characterization of bacterial pathogens in the genomics era

PE Fournier, G Dubourg, D Raoult - Genome medicine, 2014 - Springer
The availability of genome sequences obtained using next-generation sequencing (NGS)
has revolutionized the field of infectious diseases. Indeed, more than 38,000 bacterial and …

[HTML][HTML] Sequence analysis of 20,453 severe acute respiratory syndrome coronavirus 2 genomes from the Houston metropolitan area identifies the emergence and …

SW Long, RJ Olsen, PA Christensen, S Subedi… - The American journal of …, 2021 - Elsevier
Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic, there has been international concern about the emergence of virus variants with …

Transmission pathways of multidrug-resistant organisms in the hospital setting: a scoping review

N Blanco, LM O'Hara, AD Harris - Infection Control & Hospital …, 2019 - cambridge.org
Background: Prevalence of multidrug-resistant microorganisms (MDROs) continues to
increase, while infection control gaps in healthcare settings facilitate their transmission …

Evolutionary dynamics of methicillin-resistant Staphylococcus aureus within a healthcare system

LY Hsu, SR Harris, MA Chlebowicz, JA Lindsay… - Genome Biology, 2015 - Springer
Background In the past decade, several countries have seen gradual replacement of
endemic multi-resistant healthcare-associated methicillin-resistant Staphylococcus aureus …

Improved characterisation of MRSA transmission using within-host bacterial sequence diversity

MD Hall, MTG Holden, P Srisomang, W Mahavanakul… - Elife, 2019 - elifesciences.org
Methicillin-resistant Staphylococcus aureus (MRSA) transmission in the hospital setting has
been a frequent subject of investigation using bacterial genomes, but previous approaches …