Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types
of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of …

Over the past several years, studies on normal and malignant B cells have provided new
insights into the unique physiology of the germinal centre (GC). In particular, advances in …

Induced overexpression of AID in CH12F3-2 B lymphoma cells augmented class switching
from IgM to IgA without cytokine stimulation. AID deficiency caused a complete defect in …

Immunoglobulin (Ig) M+ IgD+ B cells are generally assumed to represent antigen-
inexperienced, naive B cells expressing variable (V) region genes without somatic …

Genomic instability promotes tumorigenesis and can occur through various mechanisms,
including defective segregation of chromosomes or inactivation of DNA mismatch repair …

Since the discovery in 1964 of the Epstein–Barr virus (EBV) in African Burkitt lymphoma, this
virus has been associated with a remarkably diverse range of cancer types. Because EBV …

Reciprocal chromosomal translocations involving the immunoglobulin (Ig) loci are a
hallmark of most mature B cell lymphomas and usually result in dysregulated expression of …

Abstract PCR-based immunoglobulin (Ig)/T-cell receptor (TCR) clonality testing in suspected
lymphoproliferations has largely been standardized and has consequently become …

The origin of human lymphomas has been studied by various approaches, including
histology and immunophenotyping. In some types of lymphoma these studies suggested the …

Epstein–Barr virus (EBV) is an extremely successful virus, infecting more than 90% of the
human population worldwide. After primary infection, the virus persists for the life of the host …