Key molecular events in cervical cancer development
Cervical cancer is the fourth most common cancer among women. Infection by high-risk
human papillomavirus (HPV) is the main aetiology for the development of cervical cancer …
human papillomavirus (HPV) is the main aetiology for the development of cervical cancer …
Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer
M Juríková, Ľ Danihel, Š Polák, I Varga - Acta histochemica, 2016 - Elsevier
The proliferative activity of tumour cells represents an important prognostic marker in the
diagnosis of cancer. One of the methods for assessing the proliferative activity of cells is the …
diagnosis of cancer. One of the methods for assessing the proliferative activity of cells is the …
Human PCNA structure, function, and interactions
A González-Magaña, FJ Blanco - Biomolecules, 2020 - mdpi.com
Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair.
It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA …
It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA …
Forging ahead through darkness: PCNA, still the principal conductor at the replication fork
KN Choe, GL Moldovan - Molecular cell, 2017 - cell.com
Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …
A lesson for the maestro of the replication fork: targeting the protein‐binding interface of proliferating cell nuclear antigen for anticancer therapy
VK Bhardwaj, R Purohit - Journal of Cellular Biochemistry, 2022 - Wiley Online Library
The proliferating cell nuclear antigen (PCNA) has emerged as a promising candidate for the
development of novel cancer therapeutics. PCNA is a nononcogenic mediator of DNA …
development of novel cancer therapeutics. PCNA is a nononcogenic mediator of DNA …
The many roles of PCNA in eukaryotic DNA replication
EM Boehm, MS Gildenberg, MT Washington - The Enzymes, 2016 - Elsevier
Proliferating cell nuclear antigen (PCNA) plays critical roles in many aspects of DNA
replication and replication-associated processes, including translesion synthesis, error-free …
replication and replication-associated processes, including translesion synthesis, error-free …
Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation
W Strzalka, A Ziemienowicz - Annals of botany, 2011 - academic.oup.com
Background PCNA (proliferating cell nuclear antigen) has been found in the nuclei of yeast,
plant and animal cells that undergo cell division, suggesting a function in cell cycle …
plant and animal cells that undergo cell division, suggesting a function in cell cycle …
Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
E Lazzeri, ML Angelotti, A Peired, C Conte… - Nature …, 2018 - nature.com
Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving
tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by …
tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by …
Translesion DNA polymerases in eukaryotes: what makes them tick?
A Vaisman, R Woodgate - Critical reviews in biochemistry and …, 2017 - Taylor & Francis
Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …
a complex machinery to duplicate their genomes and the central role in this machinery …
Targeting proliferating cell nuclear antigen (PCNA) as an effective strategy to inhibit tumor cell proliferation
M Cardano, C Tribioli, E Prosperi - Current cancer drug targets, 2020 - ingentaconnect.com
Targeting highly proliferating cells is an important issue for many types of aggressive tumors.
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety …
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety …