Key molecular events in cervical cancer development

SD Balasubramaniam, V Balakrishnan, CE Oon… - Medicina, 2019 - mdpi.com
Cervical cancer is the fourth most common cancer among women. Infection by high-risk
human papillomavirus (HPV) is the main aetiology for the development of cervical cancer …

Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer

M Juríková, Ľ Danihel, Š Polák, I Varga - Acta histochemica, 2016 - Elsevier
The proliferative activity of tumour cells represents an important prognostic marker in the
diagnosis of cancer. One of the methods for assessing the proliferative activity of cells is the …

Human PCNA structure, function, and interactions

A González-Magaña, FJ Blanco - Biomolecules, 2020 - mdpi.com
Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair.
It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA …

Forging ahead through darkness: PCNA, still the principal conductor at the replication fork

KN Choe, GL Moldovan - Molecular cell, 2017 - cell.com
Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …

A lesson for the maestro of the replication fork: targeting the protein‐binding interface of proliferating cell nuclear antigen for anticancer therapy

VK Bhardwaj, R Purohit - Journal of Cellular Biochemistry, 2022 - Wiley Online Library
The proliferating cell nuclear antigen (PCNA) has emerged as a promising candidate for the
development of novel cancer therapeutics. PCNA is a nononcogenic mediator of DNA …

The many roles of PCNA in eukaryotic DNA replication

EM Boehm, MS Gildenberg, MT Washington - The Enzymes, 2016 - Elsevier
Proliferating cell nuclear antigen (PCNA) plays critical roles in many aspects of DNA
replication and replication-associated processes, including translesion synthesis, error-free …

Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation

W Strzalka, A Ziemienowicz - Annals of botany, 2011 - academic.oup.com
Background PCNA (proliferating cell nuclear antigen) has been found in the nuclei of yeast,
plant and animal cells that undergo cell division, suggesting a function in cell cycle …

Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury

E Lazzeri, ML Angelotti, A Peired, C Conte… - Nature …, 2018 - nature.com
Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving
tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by …

Translesion DNA polymerases in eukaryotes: what makes them tick?

A Vaisman, R Woodgate - Critical reviews in biochemistry and …, 2017 - Taylor & Francis
Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

Targeting proliferating cell nuclear antigen (PCNA) as an effective strategy to inhibit tumor cell proliferation

M Cardano, C Tribioli, E Prosperi - Current cancer drug targets, 2020 - ingentaconnect.com
Targeting highly proliferating cells is an important issue for many types of aggressive tumors.
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety …