The outdoor air pollution and brain health workshop
Accumulating evidence suggests that outdoor air pollution may have a significant impact on
central nervous system (CNS) health and disease. To address this issue, the National …
central nervous system (CNS) health and disease. To address this issue, the National …
Roles and functions of HIV-1 Tat protein in the CNS: an overview
A Bagashev, BE Sawaya - Virology journal, 2013 - Springer
Nearly 50% of HIV-infected individuals suffer from some form of HIV-associated
neurocognitive disorders (HAND). HIV-1 Tat (a key HIV t rans a ctivator of t ranscription) …
neurocognitive disorders (HAND). HIV-1 Tat (a key HIV t rans a ctivator of t ranscription) …
Sex differences in microglial colonization of the developing rat brain
JM Schwarz, PW Sholar, SD Bilbo - Journal of neurochemistry, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 948–963. Abstract Microglia are the resident immune cells within
the brain and their production of immune molecules such as cytokines and chemokines is …
the brain and their production of immune molecules such as cytokines and chemokines is …
Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging
The widespread use of combinational antiretroviral therapies (cART) in developed countries
has changed the course of Human Immunodeficiency Virus (HIV) infection from an almost …
has changed the course of Human Immunodeficiency Virus (HIV) infection from an almost …
Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65
G Fiume, E Vecchio, A De Laurentiis… - Nucleic acids …, 2012 - academic.oup.com
Nuclear factor (NF)-κB is a master regulator of pro-inflammatory genes and is upregulated in
human immunodeficiency virus 1 (HIV-1) infection. Mechanisms underlying the NF-κB …
human immunodeficiency virus 1 (HIV-1) infection. Mechanisms underlying the NF-κB …
[HTML][HTML] Biomarkers of central and peripheral inflammation mediate the association between HIV and depressive symptoms
People living with HIV are at increased risk for depression, though the underlying
mechanisms for this are unclear. In the general population, depression is associated with …
mechanisms for this are unclear. In the general population, depression is associated with …
Ccl5–glutamate cross-talk in astrocyte-neuron communication in multiple sclerosis
A Pittaluga - Frontiers in immunology, 2017 - frontiersin.org
The immune system (IS) and the central nervous system (CNS) are functionally coupled, and
a large number of endogenous molecules (ie, the chemokines for the IS and the classic …
a large number of endogenous molecules (ie, the chemokines for the IS and the classic …
Effects of chronic HIV-1 Tat exposure in the CNS: heightened vulnerability of males versus females to changes in cell numbers, synaptic integrity, and behavior
YK Hahn, EM Podhaizer, SP Farris, MF Miles… - Brain Structure and …, 2015 - Springer
HIV-associated damage to the central nervous system results in cognitive and motor deficits.
Anti-retroviral therapies reduce the severity of symptoms, yet the proportion of patients …
Anti-retroviral therapies reduce the severity of symptoms, yet the proportion of patients …
The chemokine receptor CCR5 in the central nervous system
The expression and the role of the chemokine receptor CCR5 have been mainly studied in
the context of HIV infection. However, this protein is also expressed in the brain, where it can …
the context of HIV infection. However, this protein is also expressed in the brain, where it can …
CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward
M Gonek, VD McLane, DL Stevens, K Lippold… - Brain, behavior, and …, 2018 - Elsevier
The HIV-1 regulatory protein, trans-activator of transcription (Tat), interacts with opioids to
potentiate neuroinflammation and neurodegeneration within the CNS. These effects may …
potentiate neuroinflammation and neurodegeneration within the CNS. These effects may …