Role of interleukin-6 in cancer progression and therapeutic resistance

N Kumari, BS Dwarakanath, A Das, AN Bhatt - Tumor Biology, 2016 - Springer
In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …

[HTML][HTML] Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other …

B Giri, S Dey, T Das, M Sarkar, J Banerjee… - Biomedicine & …, 2018 - Elsevier
Chronic exposure of glucose rich environment creates several physiological and
pathophysiological changes. There are several pathways by which hyperglycemia …

The effect of short-term hyperglycemia on the innate immune system

N Jafar, H Edriss, K Nugent - The American journal of the medical sciences, 2016 - Elsevier
Background Diabetes mellitus increases the susceptibility to infection by altering both the
innate and the adaptive immune systems. Hyperglycemia has been associated with adverse …

Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways

K Huynh, BC Bernardo, JR McMullen… - Pharmacology & …, 2014 - Elsevier
Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …

The role of nutrition in asthma prevention and treatment

J Alwarith, H Kahleova, L Crosby, A Brooks… - Nutrition …, 2020 - academic.oup.com
Asthma is a chronic respiratory condition characterized by airway inflammation and
hyperreactivity. Prevalence has continued to rise in recent decades as Western dietary …

Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections

K Hodgson, J Morris, T Bridson, B Govan, C Rush… - …, 2015 - Wiley Online Library
Diabetes has been recognized as an important risk factor for a variety of intracellular
bacterial infections, but research into the dysregulated immune mechanisms contributing to …

Vitamin E, oxidative stress, and inflammation

U Singh, S Devaraj, I Jialal - Annu. Rev. Nutr., 2005 - annualreviews.org
▪ Abstract Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in
the Western world. Its incidence has also been increasing lately in developing countries …

The role of protein kinase C activation and the vascular complications of diabetes

ND Evcimen, GL King - Pharmacological research, 2007 - Elsevier
Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in
production of insulin by the pancreas, and by resistance to insulin's effects. Such a …

High glucose induces toll-like receptor expression in human monocytes: mechanism of activation

MR Dasu, S Devaraj, L Zhao, DH Hwang, I Jialal - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Hyperglycemia-induced inflammation is central in diabetes complications,
and monocytes are important in orchestrating these effects. Toll-like receptors (TLRs) play a …

Hyperglycemia associated metabolic and molecular alterations in cancer risk, progression, treatment, and mortality

P Ramteke, A Deb, V Shepal, MK Bhat - Cancers, 2019 - mdpi.com
Cancer and diabetes are amongst the leading causes of deaths worldwide. There is an
alarming rise in cancer incidences and mortality, with approximately 18.1 million new cases …