The melanin-concentrating hormone (MCH) is an important peptide implicated in the control
of motivated behaviors. History, however, made this peptide first known for its participation in …

Motivated behaviors are often initiated in response to perturbations of homeostasis. Indeed,
animals and humans have fundamental drives to procure (appetitive behaviors) and …

Given the increased prevalence of obesity and its associated comorbidities, understanding
the mechanisms through which the brain regulates energy balance is of critical importance …

Feeding behavior is a complex physiological process regulated by the interplay between
homeostatic and hedonic feeding circuits. Among the neural structures involved, the nucleus …

Obesity is a growing global epidemic that stems from the increasing availability of highly-
palatable foods and the consequent enhanced calorie consumption. Extensive research has …

Objective To explore the orexinergic pathway from the lateral hypothalamus (LHA) to the
nucleus accumbens (NAc) and its regulation on the palatable food intake. Methods …

The mesolimbic dopamine system is the primary neural circuit mediating motivation,
reinforcement, and reward-related behavior. The activity of this system and multiple …

Information seeking, such as standing on tiptoes to look around in humans, is observed
across animals and helps survival. Its rodent analog—unsupported rearing on hind legs …

Melanin‐concentrating hormone (MCH) is a conserved neuropeptide, predominantly located
in the diencephalon of vertebrates, and associated with a wide range of functions. While …

ABSTRACT BACKGROUND: Identifying biomarkers that predict substance use disorder
propensity may better strategize antiaddiction treatment. Melanin-concentrating hormone …