Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …

The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …

The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

The search for the genetic factors contributing to Alzheimer disease (AD) has evolved
tremendously throughout the years. It started from the discovery of fully penetrant mutations …

Human apolipoprotein E (ApoE) apolipoprotein is primarily expressed in three isoforms
(ApoE2, ApoE3, and ApoE4) that differ only by two residues. ApoE4 constitutes the most …

The amyloid hypothesis, which has been the predominant framework for research in
Alzheimer's disease (AD), has been the source of considerable controversy. The amyloid …

Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is
associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that …

The amyloid hypothesis has driven drug development strategies for Alzheimer's disease for
over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally …

Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of
clinical features commonly known as Down syndrome (DS). DS is among the most …

The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic
finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) …