Over the years, various liver-derived in vitro model systems have been developed to enable
investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices …

Although radiotherapy (RT) is used for the treatment of cancers, including liver cancer,
radiation-induced liver disease (RILD) has emerged as a major limitation of RT. Radiation …

One of the defining features of the liver is the capacity to maintain a constant size despite
injury. Although the precise molecular signals involved in the maintenance of liver size are …

Hepatocyte transplantation has shown potential as an additional treatment modality for
certain diseases of the liver. To date, patients with liver-based metabolic disorders or acute …

Several studies suggested the presence of stem cells in the adult normal human liver;
however, a population with stem cell properties has not yet been isolated. The purpose of …

The conception (1) and animal modeling (2) of hepatocyte transplantation along with a
partial listing of human hepatocyte infusions over the last 13 years have been detailed in …

The refinement of radiation therapy and radioembolization techniques has led to a resurgent
interest in radiation-induced liver disease (RILD). The awareness of technical and clinical …

Transplantation of the whole liver, or a portion of the liver, has been remarkably effective in
the treatment of liver failure and liver-based inherited metabolic diseases. In spite of …

This article is an updated report of a symposium held at the June 2000 annual meeting of
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …

The emerging field of regenerative medicine offers innovative methods of cell therapy and
tissue/organ engineering as a novel approach to liver disease treatment. The ultimate …