Radiation therapy is an established modality in the treatment of head and neck cancer
patients. Compromised wound healing in irradiated tissues is a common and challenging …

Cutaneous wound healing occurs in distinct yet overlapping steps with the end goal of
reforming a stratified epithelium to restore epidermal barrier function. A key component of …

Epithelial and endothelial cells possess the inherent plasticity to undergo morphological,
cellular, and molecular changes leading to their resemblance of mesenchymal cells. A …

The a and b isoforms of keratin 6 (K6), a type II intermediate filament (IF) protein, are robustly
induced upon injury to interfollicular epidermis. We previously showed that complete loss of …

Background Carcinogenesis is widely thought to originate from somatic mutations and an
inhibition of growth suppressors, followed by cell proliferation, tissue invasion, and risk of …

Wounds in the oral mucosa heal faster and more efficiently than those in the skin, although
the mechanisms underlying these differences are not completely clear. In the last 10 years, a …

Atopic dermatitis and psoriasis are members of a family of inflammatory skin disorders.
Cellular immune responses in skin tissues contribute to the development of these diseases …

Chronic wounds represent a major and growing health and economic burden worldwide. A
better understanding of molecular mechanisms of normal as well as impaired wound …

Desmosomes represent adhesive, spot-like intercellular junctions that in association with
intermediate filaments mechanically link neighboring cells and stabilize tissue architecture …

The tetraspan plasma membrane protein PERP (p53 apoptosis effector related to PMP22) is
a lesser-known transcriptional target of p53 and p63. A member of the PMP22/GAS3/EMP …