Inflammation plays a critical role in cystic fibrosis (CF) lung pathology and disease
progression making it an active area of research and important therapeutic target. In this …

Abstract T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the
effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in …

The host inflammatory response in cystic fibrosis (CF) lung disease has long been
recognized as a central pathological feature and an important therapeutic target. Indeed …

Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients.
The pulmonary immune response in CF is characterized by an early and non-resolving …

Lung infections caused by the opportunistic pathogen Pseudomonas aeruginosa can
present as a spectrum of clinical entities from a rapidly fatal pneumonia in a neutropenic …

Rationale: Cystic fibrosis (CF) is characterized by progressive pulmonary inflammation that
is infection-triggered. Pseudomonas aeruginosa represents a risk factor for deterioration of …

TH17 cells are a recently described effector CD4 T-cell subset characterized by the
production of IL-17A, IL-17F, and IL-22, which have been implicated in the pathogenesis of …

Th17 cytokines in mucosal immunity and inflammation : Current Opinion in HIV and AIDS
Th17 cytokines in mucosal immunity and inflammation : Current Opinion in HIV and AIDS Log …

Cystic fibrosis (CF) affects 70,000 patients worldwide. Morbidity and mortality in CF is largely
caused by lung complications due to the triad of impaired mucociliary clearance, microbial …

Cystic fibrosis (CF), which is caused by mutations in the gene encoding the cystic fibrosis
transmembrane conductance regulator (CFTR), is characterized by multiorgan pathology …