Diabetes mellitus (DM) is considered as a main challenge in both developing and
developed countries, as lifestyle has changed and its management seems to be vital. Type I …

Cardiac function is determined by the dynamic equilibrium of various cell types and the
extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially …

Cisplatin (DDP) was reported to improve pathological complete response (pCR) rates in
triple-negative breast cancer (TNBC) patients, however, the molecular mechanism still …

Over the past few years, the field of regulated cell death continues to expand and novel
mechanisms that orchestrate multiple regulated cell death pathways are being unveiled …

Doxorubicin (DOX) has toxic effects on the heart, causing cardiomyopathy and heart injury,
but the underlying mechanisms of these effects require further investigation. This study …

Pyroptosis is a form of cell death mediated by gasdermin D (GSDMD); it is characterised by
NLRP3 inflammasome activation, caspase activation, cell membrane pore formation, and …

Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and
apoptosis, pyroptosis has unique characteristics in morphology and mechanism …

The epidemic of diabetes mellitus (DM) necessitates the development of novel therapeutic
and preventative strategies to attenuate complications of this debilitating disease. Diabetic …

Abstract Kcnq1 overlapping transcript 1 (kcnq1ot1), an imprinted antisense lncRNA in the
kcnq1 locus, acts as a potential contributor to cardiovascular disease, but its role in …

The cellular signaling network involves co-ordinated regulation of numerous signaling
molecules that aid the maintenance of cellular as well as organismal homeostasis. Aberrant …