The terminal differentiation of osteoblasts and subsequent formation of bone marks an
important phase in palate development that leads to the separation of the oral and nasal …

The craniofacial region comprises the most complex and intricate anatomical structures in
the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue …

Abnormal craniofacial bone fusion can lead to the generation of several congenital
malformations such as cleft palate, craniosynostosis and craniofacial skeletal hypoplasia …

Apert syndrome is a rare genetic disorder characterized by craniosynostosis, midface
retrusion, and limb anomalies. Cleft palate occurs in a subset of Apert syndrome patients …

The current standard of care for an alveolar cleft defect is an autogenous bone graft, typically
from the iliac crest. Given the limitations of alveolar bone graft surgery, such as limited …

Cleft lip and/or palate (CLP) is a prevalent congenital craniofacial abnormality that can lead
to difficulties in eating, speaking, hearing, and psychological distress. The traditional …

Cleft palate is one of the most common birth defects. Previous studies revealed that multiple
factors, including impaired intracellular or intercellular signals, and incoordination of oral …

Congenital craniofacial abnormalities are congenital anomalies of variable expressivity and
severity with a recognizable set of abnormalities, which are derived from five identifiable …

Vascular endothelial growth factor A (VEGFA) is a crucial growth factor, which participates in
multiple processes of human growth and development, such as angiogenesis and …

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the Creative Commons Attribution License (CC BY). The use, distribution and reproduction …