The accumulation of pathogenic protein oligomers and aggregates is associated with
several devastating amyloid diseases. As protein aggregation is a multi-step nucleation …

Amyloid fibrils are insoluble, fibrous nanostructures that accumulate extracellularly in
biological tissue during the progression of several human disorders, including Alzheimer's …

Several devastating human diseases are linked to peptide self-assembly, but our
understanding their onset and progression is not settled. This is a sign of the complexity of …

Online monitoring by flow NMR spectroscopy is a powerful approach to study chemical
reactions and processes, which can provide mechanistic understanding, and drive …

Protein misfolding and self-assembling into amyloid structures are associated with a number
of diseases. Characterization of protein amyloid formation reactions is a challenging task as …

Biophysical chemistry deals with the structural behavior, properties and molecular function
of biological macromolecules. A long-standing challenge is here to establish how these …

La spectroscopie de résonance magnétique nucléaire (RMN) est une méthode
particulièrement utile pour analyser la composition d'un mélange. Au sein de la panoplie …

Ces travaux de thèse présentent les différentes approches explorées dans le but de
développer une méthode d'étude du mode d'interaction en solution entre un complexe de …