Selenium is an essential trace element that is crucial for cellular antioxidant defense against
reactive oxygen species (ROS). Recently, many selenium-containing compounds have …

Oxidative stress involves the increased production and accumulation of free radicals,
peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS) …

The interest in the synthesis of Se-containing compounds is growing with the discovery of
derivatives exhibiting various biological activities. In this manuscript, we have identified a …

Selenium, originally described as a toxin, turns out to be a crucial trace element for life that
appears as selenocysteine and its dimer, selenocystine. From the point of view of drug …

Recent, many methods have been reported for the synthesis of selenium-containing
bioactive scaffolds because of their interesting reactivity and potential pharmaceutical …

Mammalian thioredoxin reductase (TrxR) enzymes are homodimeric flavin proteins sharing
a unique yet essential selenocysteine residue at their C‐terminus. TrxRs, together with their …

Increasing antibiotic resistance makes the identification of new antibacterial principles an
urgent task. The thioredoxin system including thioredoxin reductase (TrxR), thioredoxin …

The COVID‐19 pandemic caused by the SARS‐CoV‐2 has mobilized scientific attention in
search of a treatment. The cysteine‐proteases, main protease (Mpro) and papain‐like …

Kidney-type glutaminase [KGA/isoenzyme glutaminase C (GAC)] is becoming an important
tumor metabolism target in cancer chemotherapy. Its allosteric inhibitor, CB839, showed …

Recent advances in the chemistry of selenium-containing heterocycles: Five-membered ring
systems - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …