Osteoclasts (OCLs) are key players in controlling bone remodeling. Modifications in their
differentiation or bone resorbing activity are associated with a number of pathologies …

Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It
possesses a wide range of medicinal properties suggesting its potential clinical utility that …

Bone remodelling is a dynamic process required for the maintenance of bone architecture in
response to the changing mechanical needs. It is also a vital process during the repair of …

Chronic inflammation during many diseases is associated with bone loss. While interferons
(IFNs) are often inhibitory to osteoclast formation, the complex role that IFN and interferon …

Cholesteatoma, which potentially results from tympanic membrane retraction, is
characterized by intractable local bone erosion and subsequent hearing loss and brain …

Irisin, a skeletal-muscle secreted myokine, facilitates muscle-bone crosstalk and skeletal
remodeling in part by its action on osteoblasts and osteocytes. In this study, we investigated …

Women gradually lose bone from the age of~ 35 years, but around menopause, the rate of
bone loss escalates due to increasing bone resorption and decreasing bone formation …

Interest in space exploration has seen substantial growth following recent launch and
operation of modern space technologies. In particular, the possibility of travel beyond low …

Osteoclastic bone resorption and osteoblastic bone formation/replenishment are closely
coupled in bone metabolism. Anabolic parathyroid hormone (PTH), which is commonly used …

Background Rapid, non-genomic estrogen receptor (ER) signaling plays an integral role in
mediating the tissue selective properties of ER modulators. Icariin, a bone bioactive …