T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …

Cancer immunotherapy offers substantive benefit to patients with various tumour types, in
some cases leading to complete tumour clearance. However, many patients do not respond …

Background Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and
subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro …

Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …

Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …

Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …

Abstract Interleukin-33 (IL-33), an epithelial cell-derived cytokine that responds rapidly to
environmental insult, has a critical role in initiating airway inflammatory diseases. However …

Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) family that is expressed in the
nuclei of endothelial and epithelial cells of barrier tissues, among others. It functions as an …

Regulatory T (Treg) cells, possess a strategic role in the maintenance of immune
homeostasis, and their function has been closely linked to development of diverse …