The histone H3 family and its deposition pathways
D Ray-Gallet, G Almouzni - Histone Mutations and Cancer, 2021 - Springer
Within the cell nucleus, the organization of the eukaryotic DNA into chromatin uses histones
as components of its building block, the nucleosome. This chromatin organization …
as components of its building block, the nucleosome. This chromatin organization …
Potential coordination role between O-GlcNAcylation and epigenetics
D Wu, Y Cai, J Jin - Protein & cell, 2017 - academic.oup.com
Dynamic changes of the post-translational O-GlcNAc modification (O-GlcNAcylation) are
controlled by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) and the …
controlled by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) and the …
Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition
The tumor suppressor gene ATRX is frequently mutated in a variety of tumors including
gliomas and liver cancers, which are highly unresponsive to current therapies. Here, we …
gliomas and liver cancers, which are highly unresponsive to current therapies. Here, we …
Structure of the Hir histone chaperone complex
HJ Kim, MR Szurgot, T van Eeuwen, MD Ricketts… - Molecular Cell, 2024 - cell.com
The evolutionarily conserved HIRA/Hir histone chaperone complex and ASF1a/Asf1 co-
chaperone cooperate to deposit histone (H3/H4) 2 tetramers on DNA for replication …
chaperone cooperate to deposit histone (H3/H4) 2 tetramers on DNA for replication …
HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3. 3 and H2A. Z on the poised genes in mESCs
Y Yang, L Zhang, C Xiong, J Chen, L Wang… - Nucleic acids …, 2022 - academic.oup.com
Histone variants have been implicated in regulating chromatin dynamics and genome
functions. Previously, we have shown that histone variant H3. 3 actively marks enhancers …
functions. Previously, we have shown that histone variant H3. 3 actively marks enhancers …
Functional activity of the H3. 3 histone chaperone complex HIRA requires trimerization of the HIRA subunit
The HIRA histone chaperone complex deposits the histone variant H3. 3 onto chromatin in a
DNA synthesis-independent manner. It comprises three identified subunits, HIRA, UBN1 and …
DNA synthesis-independent manner. It comprises three identified subunits, HIRA, UBN1 and …
HIRA stabilizes skeletal muscle lineage identity
The epigenetic mechanisms coordinating the maintenance of adult cellular lineages and the
inhibition of alternative cell fates remain poorly understood. Here we show that targeted …
inhibition of alternative cell fates remain poorly understood. Here we show that targeted …
Differential Expression of Histone H3.3 Genes and Their Role in Modulating Temperature Stress Response in Caenorhabditis elegans
Abstract Histone H3. 3, a major variant of canonical histone H3, is highly conserved and
essential for viability or fertility in most lineages. In Caenorhabditis elegans, H3. 3 is …
essential for viability or fertility in most lineages. In Caenorhabditis elegans, H3. 3 is …
[HTML][HTML] The histone variant H3. 3 claims its place in the crowded scene of epigenetics
D Bano, A Piazzesi, P Salomoni, P Nicotera - Aging (Albany NY), 2017 - ncbi.nlm.nih.gov
Histones are evolutionarily conserved DNA-binding proteins. As scaffolding molecules, they
significantly regulate the DNA packaging into the nucleus of all eukaryotic cells. As docking …
significantly regulate the DNA packaging into the nucleus of all eukaryotic cells. As docking …
Recurrent herpes simplex virus type 1 (HSV-1) infection modulates neuronal aging marks in in vitro and in vivo models
G Napoletani, V Protto, ME Marcocci… - International Journal of …, 2021 - mdpi.com
Herpes simplex virus 1 (HSV-1) is a widespread neurotropic virus establishing a life-long
latent infection in neurons with periodic reactivations. Recent studies linked HSV-1 to …
latent infection in neurons with periodic reactivations. Recent studies linked HSV-1 to …