Neuropharmacological effects of quercetin: a literature-based review

MS Islam, C Quispe, R Hossain, MT Islam… - Frontiers in …, 2021 - frontiersin.org
Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its
beneficial properties in many pathologies. Its neuroprotective effects have been …

Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions

N Suganthy, KP Devi, SF Nabavi, N Braidy… - Biomedicine & …, 2016 - Elsevier
Quercetin, a ubiquitous flavonoid that is widely distributed in plants is classified as a
cognitive enhancer in traditional and oriental medicine. The protective effects of quercetin for …

Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish

N Rishitha, A Muthuraman - Life sciences, 2018 - Elsevier
Background Quercetin is a major flavonoid in various plants. It possesses the multiple
pharmacological actions like vascular integrity and regulatory action of the blood-brain …

Dietary flavonoids interaction with CREB-BDNF pathway: An unconventional approach for comprehensive management of epilepsy

P Sharma, A Kumar, D Singh - Current neuropharmacology, 2019 - ingentaconnect.com
cAMP response element binding protein (CREB) is a key transcriptional regulator that
regulates the transcription of genes related with neuronal differentiation, synaptic plasticity …

Enlightening the neuroprotective effect of quercetin in epilepsy: From mechanism to therapeutic opportunities

E Akyuz, YN Paudel, AK Polat, HE Dundar… - Epilepsy & Behavior, 2021 - Elsevier
Epilepsy is a devastating neurological disorder characterized by the repeated occurrence of
epileptic seizures. Epilepsy stands as a global health concern affecting around 70 million …

Machine learning assisted-nanomedicine using magnetic nanoparticles for central nervous system diseases

A Tomitaka, A Vashist, N Kolishetti, M Nair - Nanoscale Advances, 2023 - pubs.rsc.org
Magnetic nanoparticles possess unique properties distinct from other types of nanoparticles
developed for biomedical applications. Their unique magnetic properties and …

Anticonvulsant effect of quercetin in pentylenetetrazole (PTZ)-induced seizures in male mice: The role of anti-neuroinflammatory and anti-oxidative stress

Z Tavakoli, HT Dehkordi, Z Lorigooini… - International …, 2023 - Elsevier
Background Epilepsy is one of the major neurological disorders. The inflammatory process
and oxidative stress are closely related to seizure progression. Quercetin is a flavonoid with …

Proanthocyanidins alleviate pentylenetetrazole-induced epileptic seizures in mice via the antioxidant activity

NM Alyami, S Abdi, HM Alyami, R Almeer - Neurochemical Research, 2022 - Springer
The role of oxidative stress in the initiation and progress of epilepsy is well established.
Proanthocyanidins (PACs), a naturally occurring polyphenolic compound, have been …

Reduced expression of hippocampal GluN2A-NMDAR increases seizure susceptibility and causes deficits in contextual memory

MF Acutain, J Griebler Luft, CA Vazquez… - Frontiers in …, 2021 - frontiersin.org
N-methyl-d-aspartate receptors are heterotetramers composed of two GluN1 obligatory
subunits and two regulatory subunits. In cognitive-related brain structures, GluN2A and …

Single step nanospray drying preparation technique of gabapentin-loaded nanoparticles-mediated brain delivery for effective treatment of PTZ-induced seizures

AH Salama, AAA Salama, M Elhabak - International Journal of …, 2021 - Elsevier
In the present study, gabapentin (GBP)-loaded chitosan nanosized particles were fabricated
applying the nanospray drying technique. Different preparation parameters (spray mesh …