Overcoming skin barriers through advanced transdermal drug delivery approaches

V Phatale, KK Vaiphei, S Jha, D Patil, M Agrawal… - Journal of controlled …, 2022 - Elsevier
Upon exhaustive research, the transdermal drug delivery system (TDDS) has appeared as a
potential, well-accepted, and popular approach to a novel drug delivery system. Ease of …

Cutaneous barriers and skin immunity: differentiating a connected network

S Eyerich, K Eyerich, C Traidl-Hoffmann… - Trends in …, 2018 - cell.com
The skin is the outermost barrier of the organism that ensures protection from external harm.
Lately, our view of the skin has evolved from an inert mechanical barrier to an active organ …

[HTML][HTML] Five functional aspects of the epidermal barrier

A Lefèvre-Utile, C Braun, M Haftek, F Aubin - International journal of …, 2021 - mdpi.com
The epidermis is a living, multilayered barrier with five functional levels, including a physical,
a chemical, a microbial, a neuronal, and an immune level. Altogether, this complex organ …

[HTML][HTML] Impact of airborne particulate matter on skin: A systematic review from epidemiology to in vitro studies

IM Dijkhoff, B Drasler, BB Karakocak… - Particle and fibre …, 2020 - Springer
Background Air pollution is killing close to 5 million people a year, and harming billions
more. Air pollution levels remain extremely high in many parts of the world, and air pollution …

[HTML][HTML] Skin barriers in dermal drug delivery: which barriers have to be overcome and how can we measure them?

C Gorzelanny, C Mess, SW Schneider, V Huck… - Pharmaceutics, 2020 - mdpi.com
Although, drugs are required in the various skin compartments such as viable epidermis,
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …

[HTML][HTML] Skin barrier dysregulation in psoriasis

A Orsmond, L Bereza-Malcolm, T Lynch… - International journal of …, 2021 - mdpi.com
The skin barrier is broadly composed of two elements—a physical barrier mostly localised in
the epidermis, and an immune barrier localised in both the dermis and epidermis. These two …

3D skin models for 3R research: The potential of 3D reconstructed skin models to study skin barrier function

H Niehues, JA Bouwstra, A El Ghalbzouri… - Experimental …, 2018 - Wiley Online Library
The skin barrier is an important shield regulating the outside‐in as well as inside‐out
penetration of water, nutrients, ions and environmental stimuli. We can distinguish four …

Wound healing applications of creams and “smart” hydrogels

D Stan, C Tanase, M Avram, R Apetrei… - Experimental …, 2021 - Wiley Online Library
Although superficial wounds are often easy to treat for healthy individuals, there are some
more severe types of wounds (burns, ulcers, diabetic wounds, etc.) that are a challenge for …

Hypoxia and innate immunity: keeping up with the HIFsters

SP Colgan, GT Furuta, CT Taylor - Annual review of …, 2020 - annualreviews.org
Recent years have witnessed an emergence of interest in understanding metabolic changes
associated with immune responses, termed immunometabolism. As oxygen is central to all …

Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion

R Choa, J Tohyama, S Wada, H Meng, J Hu… - Science, 2021 - science.org
INTRODUCTION Obesity and its associated complications are serious global concerns.
Despite growing public health initiatives, obesity rates continue to rise. Thus, there is a …