Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce heart failure events by
direct action on the failing heart that is independent of changes in renal tubular function. In …

The hexosamine biosynthetic pathway (HBP) produces uridine diphosphate N-
acetylglucosamine (UDP-GlcNAc) to facilitate O-linked GlcNAc (O-GlcNAc) protein …

In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Pyroptosis is a type of regulated cell death executed by gasdermin family members.
However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear …

The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-N-acetyl
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …

Background: The integrated stress response (ISR) is an evolutionarily conserved process to
cope with intracellular and extracellular disturbances. Myocardial infarction is a leading …

Takotsubo cardiomyopathy is a stress-induced cardiovascular disease with symptoms
comparable to those of an acute coronary syndrome but without coronary obstruction …