Background: Colorectal cancer (CRC) is one of the most common cancers all over the world,
but its epidemiology is obviously different in various regions. Methods: The treatment of CRC …

Dramatic improvements in the outcomes of patients with rectal cancer have occurred over
the past 30 years. Advances in surgical pathology, refinements in surgical techniques and …

This selection from the NCCN Guidelines for Rectal Cancer focuses on management of
malignant polyps and resectable nonmetastatic rectal cancer because important updates …

Background Neoadjuvant chemotherapy and radiation followed by surgical resection of the
rectum is a standard treatment for locally advanced rectal cancer. A subset of rectal cancer is …

Rectal cancer (RC) is a challenging disease to treat that requires chemotherapy, radiation
and surgery to optimize outcomes for individual patients. No accurate model of RC exists to …

Importance The watch-and-wait (WW) strategy aims to spare patients with rectal cancer
unnecessary resection. Objective To analyze the outcomes of WW among patients with …

The NCCN Guidelines for Rectal Cancer provide recommendations for the diagnosis,
evaluation, treatment, and follow-up of patients with rectal cancer. These NCCN Guidelines …

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Rectal Cancer
address diagnosis, staging, surgical management, perioperative treatment, management of …

Importance Treatment of locally advanced rectal (LARC) cancer involves chemoradiation,
surgery, and chemotherapy. The concept of total neoadjuvant therapy (TNT), in which …

Longitudinal analysis of circulating tumor DNA (ctDNA) has shown promise for monitoring
treatment response. However, most current methods lack adequate sensitivity for residual …